Manual leukocyte differential count: is it time for retirement?

The leukocyte differential count is one of the most frequent laboratory analyses, mainly used to diagnose or monitor conditions such as infections, vitamin deficiencies, or hematological malignancies. In most modern laboratories, the leukocyte differential count is performed in cell counters, called hematoanalyzers, which perform a very basic flow cytometric analysis. These hematoanalyzers provide fast and accurate results in a fully automated manner, but in approximately 10-20% of the analyzed samples, they produce a so-called “flag” and require further evaluation [1]Kobe, Japan, has developed new software for its XE-5000 with improved algorithms for flagging blast cells, abnormal lymphocytes or lymphoblasts, and atypical lymphocytes.



Det här är ett utplock av en intressant artikel från KBN – Nr. 2 – vol. 37 – 2025.